Sangram "Sam" Sisodia: Advancing Science, Inspiring Generations

In this seven-part series, we’re excited to highlight our 2025 Franklin alumni award winners—showcasing their accomplishments and providing some insights as we seek this year’s nominations. The Franklin College of Arts and Sciences Alumni Awards honor outstanding alumni across various categories. These individuals exemplify the Franklin Spark, the characteristics that unite the arts and sciences: ambition, curiosity, creativity, innovation and leadership, throughout their industries and communities.  

Nominations can be made through September 30 across eight categories: College-Service Award, Distinguished Alumni Award, Family Award, Innovation Award, Lifetime Award, Mid-Career Award, Organization Award, and Young Alumni Award. 

 Sangram “Sam” Sisodia (PhD Biochemistry ’95) has spent his career at the cutting-edge of neuroscience, transforming how we understand one of the most complex and devastating diseases of our time: Alzheimer’s. Sisodia has become a global leader in neurodegenerative research, known for his groundbreaking work on the molecular and cellular mechanisms that drive inherited forms of the disease. In recognition of his remarkable career and enduring contributions, Sisodia was awarded Franklin’s 2025 Alumni of Distinction. 

Currently the Thomas A. Reynolds Sr. Family Professor of Neurobiology in the Departments of Neurobiology and Neurology at the University of Chicago, Sisodia’s research centers on two key proteins: amyloid precursor protein (APP) and presenilins (PS1 and PS2). Mutations in these polypeptides are known to cause familial Alzheimer’s disease (FAD), and his work has been instrumental in revealing how these mutations lead to the buildup of amyloid plaques—disrupting memory and brain function. 

Sisodia has pioneered breakthroughs that have changed the field. One of his most influential contributions was the development of experimental models that replicate the effects of Alzheimer’s in the brain. These models have become foundational tools for researchers globally, helping to uncover why certain brain cells are more vulnerable and how environmental factors may influence disease progression.  

With 177 peer-reviewed publications, Sisodia’s scientific output reflects both the depth and significance of his work. His research continues to guide new therapeutic approaches and deepen our understanding of neurodegenerative processes. 

Sisodia’s commitment to science extends beyond the lab. In 2020, he established the Sisodia-Patel Prize in Biochemistry and Molecular Biology at UGA’s Franklin College of Arts and Sciences, supporting graduating seniors pursuing graduate studies in the sciences. He also served as an emeritus member of the Graduate Education Advancement Board, helping shape the academic community that launched his own career. 

Sisodia’s journey is a testament to the power of curiosity, perseverance, and generosity. His work has brought us closer to understanding Alzheimer’s disease—and his dedication to mentoring young scientists ensures that the pursuit of discovery will continue for generations to come. 

For more information on the Franklin College of Arts and Sciences Alumni Awards and previous winners, click here. 

To submit a nomination, click here.